top of page

Virology and Epidemiology

 

  • Hui RK, Leung FC. Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus. PLoS One. 2015 Jun 8;10(6):e0111771. doi: 10.1371/journal.pone.0111771. eCollection 2015. PMID:26053856

  • Lu WH, Tun HM, Sun BL, Mo J, Zhou QF, Deng YX, Xie QM, Bi YZ, Leung FC, Ma JY. Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant. Vet Microbiol. 2015 Feb 25;175(2-4):332-40. doi: 10.1016/j.vetmic.2014.11.016. Epub 2014 Dec 3. PMID:25529828

  • Brar MS, Shi M, Hui RK, Leung FC. Genomic evolution of porcine reproductive and respiratory syndrome virus (PRRSV) isolates revealed by deep sequencing. PLoS One. 2014;9(4):e88807. doi: 10.1371/journal.pone.0088807. PMID:24698958

  • Kvisgaard LK, Hjulsager CK, Brar MS, Leung FC, Larsen LE. Genetic dissection of complete genomes of Type 2 PRRS viruses isolated in Denmark over a period of 15 years. Vet Microbiol. 2013 Dec 27;167(3-4):334-44. doi: 10.1016/j.vetmic.2013.09.023. Epub 2013 Sep 25. PMID:24125764

  • Shi M, Holmes EC, Brar MS, Leung FC. Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China. J Virol. 2013 Oct;87(19):10904-7. doi: 10.1128/JVI.01270-13. Epub 2013 Jul 24. PMID:23885071

  • Hoque MA, Tun HM, Hassan MM, Khan SA, Islam SA, Islam MN, Giasuddin M, Osmani TM, Islam A, Thornton RN, Burgess GW, Skerratt LF, Selleck P, Brun E, Debnath NC, Leung FC. Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011. Prev Vet Med. 2013 Sep 1;111(3-4):314-8. doi: 10.1016/j.prevetmed.2013.06.003. Epub 2013 Jun 29. PMID:23820377

  • Lam TT, Chong YL, Shi M, Hon CC, Li J, Martin DP, Tang JW, Mok CK, Shih SR, Yip CW, Jiang J, Hui RK, Pybus OG, Holmes EC, Leung FC. Systematic phylogenetic analysis of influenza A virus reveals many novel mosaic genome segments. Infect Genet Evol. 2013 Aug;18:367-78. doi: 10.1016/j.meegid.2013.03.015. Epub 2013 Mar 30. PMID:23548803

  • Li KK, Yip CW, Hon CC, Lam CY, Zeng F, Leung FC. Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection. Hong Kong Med J. 2012 Aug;18 Suppl 3:35-8. No abstract available. PMID:22865222

  • Lam TT, Hon CC, Lemey P, Pybus OG, Shi M, Tun HM, Li J, Jiang J, Holmes EC, Leung FC. Phylodynamics of H5N1 avian influenza virus in Indonesia. Mol Ecol. 2012 Jun;21(12):3062-77. doi: 10.1111/j.1365-294X.2012.05577.x. Epub 2012 May 11. PMID:22574738

  • Hui RK, Leung FC. Evolutionary trend of foot-and-mouth disease virus in Hong Kong. Vet Microbiol. 2012 Sep 14;159(1-2):221-9. doi: 10.1016/j.vetmic.2012.03.016. Epub 2012 Mar 16. PMID:22472703

  • Yip CW, Hon CC, Zeng F, Leung FC. Cell culture-adapted IBDV uses endocytosis for entry in DF-1 chicken embryonic fibroblasts. Virus Res. 2012 Apr;165(1):9-16. doi: 10.1016/j.virusres.2011.12.016. Epub 2011 Dec 31. PMID:22230315

  • Van Doorsselaere J, Brar MS, Shi M, Karniychuk U, Leung FC, Nauwynck HJ. Complete genome characterization of a East European Type 1 subtype 3 porcine reproductive and respiratory syndrome virus. Virus Genes. 2012 Feb;44(1):51-4. doi: 10.1007/s11262-011-0665-x. Epub 2011 Sep 27. PMID:21948018

  • Cai S, Li J, Wong MT, Jiao P, Fan H, Liu D, Liao M, Jiang J, Shi M, Lam TT, Ren T, Leung FC. Genetic characterization and evolutionary analysis of 4 Newcastle disease virus isolate full genomes from waterbirds in South China during 2003-2007. Vet Microbiol. 2011 Aug 26;152(1-2):46-54. doi: 10.1016/j.vetmic.2011.04.014. Epub 2011 Apr 22. PMID:21565454

  • Tun HM, Shi M, Wong CL, Ayudhya SN, Amonsin A, Thanawonguwech R, Leung FC. Genetic diversity and multiple introductions of porcine reproductive and respiratory syndrome viruses in Thailand. Virol J. 2011 Apr 12;8:164. doi: 10.1186/1743-422X-8-164. PMID:21486451

  • Brar MS, Shi M, Ge L, Carman S, Murtaugh MP, Leung FC. Porcine reproductive and respiratory syndrome virus in Ontario, Canada 1999 to 2010: genetic diversity and restriction fragment length polymorphisms. J Gen Virol. 2011 Jun;92(Pt 6):1391-7. doi: 10.1099/vir.0.030155-0. Epub 2011 Feb 23. PMID:21346028

  • Shi M, Lam TT, Hon CC, Hui RK, Faaberg KS, Wennblom T, Murtaugh MP, Stadejek T, Leung FC. Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res. 2010 Dec;154(1-2):7-17. doi: 10.1016/j.virusres.2010.08.014. Epub 2010 Sep 15. Review. PMID:20837072

  • Murtaugh MP, Stadejek T, Abrahante JE, Lam TT, Leung FC. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res. 2010 Dec;154(1-2):18-30. doi: 10.1016/j.virusres.2010.08.015. Epub 2010 Aug 27. Review. PMID:20801173

  • Shi M, Lam TT, Hon CC, Murtaugh MP, Davies PR, Hui RK, Li J, Wong LT, Yip CW, Jiang JW, Leung FC. Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses. J Virol. 2010 Sep;84(17):8700-11. doi: 10.1128/JVI.02551-09. Epub 2010 Jun 16. PMID:20554771

  • Yuan J, Hon CC, Li Y, Wang D, Xu G, Zhang H, Zhou P, Poon LL, Lam TT, Leung FC, Shi Z. Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans. J Gen Virol. 2010 Apr;91(Pt 4):1058-62. doi: 10.1099/vir.0.016378-0. Epub 2009 Dec 16. PMID:20016037

  • Yip CW, Hon CC, Shi M, Lam TT, Chow KY, Zeng F, Leung FC. Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses. Infect Genet Evol. 2009 Dec;9(6):1185-96. doi: 10.1016/j.meegid.2009.09.015. Epub 2009 Sep 30. Review. PMID:19800030

  • Chow KY, Yeung YS, Hon CC, Zeng F, Law KM, Leung FC. SARS coronavirus and apoptosis. Hong Kong Med J. 2008 Aug;14 Suppl 4:8-13. PMID:18708667

  • Hon CC, Lam TT, Yip CW, Wong RT, Shi M, Jiang J, Zeng F, Leung FC. Phylogenetic evidence for homologous recombination within the family Birnaviridae. J Gen Virol. 2008 Dec;89(Pt 12):3156-64. doi: 10.1099/vir.0.2008/004101-0. PMID:19008406

  • Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F, Leung FC. Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia. PLoS Pathog. 2008 Aug 22;4(8):e1000130. doi: 10.1371/journal.ppat.1000130. PMID:18725937

  • Hon CC, Lam TY, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. J Virol. 2008 Feb;82(4):1819-26. Epub 2007 Dec 5. PMID:18057240

  • Yeung YS, Yip CW, Hon CC, Chow KY, Ma IC, Zeng F, Leung FC. Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: insights on viral regulation of apoptosis and proliferation. Virology. 2008 Feb 5;371(1):32-43. Epub 2007 Oct 24. PMID:17961624

  • Lam TY, Hon CC, Wang Z, Hui RK, Zeng F, Leung FC. Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events. Virus Res. 2008 Feb;131(2):271-8. Epub 2007 Oct 23. PMID:17936394

  • Lam TT, Hon CC, Lam PY, Yip CW, Zeng F, Leung FC. Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic. Vet Microbiol. 2008 Jan 25;126(4):390-3. Epub 2007 Aug 17. No abstract available. PMID:17884305 

  • Wong RT, Hon CC, Zeng F, Leung FC. Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays. J Gen Virol. 2007 Jun;88(Pt 6):1785-96. PMID:17485540

  • Ma CM, Hon CC, Lam TY, Li VY, Wong CK, de Oliveira T, Leung FC. Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China. J Gen Virol. 2007 Jun;88(Pt 6):1733-7. PMID:17485533

  • Leung FC. Comments on the Fujian-like strain of avian influenza H5N1. Poult Sci. 2007 Mar;86(3):435-6; author reply 437-8. No abstract available. PMID:17297151

  • Yip CW, Hon CC, Zeng F, Chow KY, Chan KH, Peiris JS, Leung FC. Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome. Clin Vaccine Immunol. 2007 Jan;14(1):99-101. Epub 2006 Nov 15. PMID:17108287

  • Zeng F, Hon CC, Yip CW, Law KM, Yeung YS, Chan KH, Malik Peiris JS, Leung FC. Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of receptor binding: implications for the functional roles of S2 subunit. FEBS Lett. 2006 Oct 16;580(24):5612-20. Epub 2006 Sep 12. PMID:16989815

  • Yip CW, Yeung YS, Ma CM, Lam PY, Hon CC, Zeng F, Leung FC. Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells. Virus Res. 2007 Jan;123(1):50-6. Epub 2006 Sep 11. PMID:16965830

  • Hon CC, Lam TY, Drummond A, Rambaut A, Lee YF, Yip CW, Zeng F, Lam PY, Ng PT, Leung FC. Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B. J Virol. 2006 Sep;80(17):8503-9. PMID:16912300

  • Jinding C, Mingqiu Z, Hui KH, Leung FC. Molecular characterization of foot-and-mouth disease virus in Hong Kong during 2001-2002. Virus Genes. 2006 Apr;32(2):139-43. PMID:16604445

  • Chow KY, Yeung YS, Hon CC, Zeng F, Law KM, Leung FC. Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells. FEBS Lett. 2005 Dec 19;579(30):6699-704. Epub 2005 Nov 21. PMID:16310778

  • Chow KY, Hon CC, Hui RK, Wong RT, Yip CW, Zeng F, Leung FC. Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Genomics Proteomics Bioinformatics. 2003 Nov;1(4):247-62. Review. PMID:15629054

  • Yip CW, Hon CC, Zeng F, Chow KY, Leung FC. Prevalence of non-pneumonic infections with SARS-correlated virus. Lancet. 2004 May 29;363(9423):1825; author reply 1826-7. No abstract available. PMID:15172784

  • Hui RK, Zeng F, Chan CM, Yuen KY, Peiris JS, Leung FC. Reverse transcriptase PCR diagnostic assay for the coronavirus associated with severe acute respiratory syndrome. J Clin Microbiol. 2004 May;42(5):1994-9. PMID:15131160

  • Zeng F, Chow KY, Hon CC, Law KM, Yip CW, Chan KH, Peiris JS, Leung FC. Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments. Biochem Biophys Res Commun. 2004 Mar 19;315(4):1134-9. PMID:14985131

  • Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet. 2004 Jan 10;363(9403):99-104. PMID:14726162

  • Zeng F, Chow KY, Leung FC. Estimated timing of the last common ancestor of the SARS coronavirus. N Engl J Med. 2003 Dec 18;349(25):2469-70. No abstract available. PMID:14681521

  • Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang CY, Wang PY, Guan Y, Zheng B, Poon LL, Chan KH, Yuen KY, Peiris JS, Leung FC. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39). Exp Biol Med (Maywood). 2003 Jul;228(7):866-73. PMID:12876307

  • Leung FC. Hong Kong SARS sequence. Science. 2003 Jul 18;301(5631):309-10. No abstract available. PMID:12869741

  • Cao YC, Yeung WS, Law M, Bi YZ, Leung FC, Lim BL. Molecular characterization of seven Chinese isolates of infectious bursal disease virus: classical, very virulent, and variant strains. Avian Dis. 1998 Apr-Jun;42(2):340-51. PMID:9645325

bottom of page